Section: New Results

Coupled Model of the Cell Cycle and Circadian Clock

Participants : François Fages, Sylvain Soliman, Denis Thieffry, Pauline Traynard.

Recent advances in cancer chronotherapy techniques support the evidence that there exist important links between the cell cycle and the circadian clock genes. One purpose for modeling these links is to better understand how to efficiently target malignant cells depending on the phase of the day and patient characterictics. This is at the heart of our participation in collaboration with the EPI BANG in the EraNet SysBio project C5Sys , follow up of the former EU STREP project TEMPO.

This year we have pursued the investigation of the effect of transcription inhibition during mitosis, as a reverse coupling from the cell cycle to the circadian clock. We use quantitative temporal logic constraints and the parallel version of BIOCHAM for parameter search, running on the Jade cluster of 10000 processors at the GENCI CINES, to couple dynamical models in high dimension and fit models to experimental data time series obtained in Franck Delaunay's lab in Nice, CNRS. We are defining a series of common temporal logic patterns and ad hoc schemes for computing their validity domain on a given trace, more efficiently than by the generic method implemented in BIOCHAM.